Antitumour activity of the recombination polypeptide GST-NT21MP is mediated by inhibition of CXCR4 pathway in breast cancer
نویسندگان
چکیده
Q Yang, F Zhang, Y Ding, J Huang, S Chen, Q Wu, Z Wang, Z Wang* and C Chen* Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui 233030, China; Clinical Testing and Diagnose Experimental Center of Bengbu Medical College, Anhui 233000, China; Branch of Tumour of the Center Hospital of Bengbu, Anhui 233000, China; Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA and Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, China
منابع مشابه
The N-terminal polypeptide derived from viral macrophage inflammatory protein II reverses breast cancer epithelial-to-mesenchymal transition via a PDGFRα-dependent mechanism
NT21MP, a 21-residue peptide derived from the viral macrophage inflammatory protein II, competed effectively with the natural ligand of CXC chemokine receptor 4 (CXCR4), stromal cell-derived factor 1-alpha, to induce apoptosis and inhibit growth in breast cancer. Its role in tumor epithelial-to-mesenchymal transition (EMT) regulation remains unknown. In this study, we evaluated the reversal of ...
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